This is frequently reported, particularly when first trying an oral nicotine pouch or a new strength. You might notice:

• Gum irritation or a burning sensation where the pouch is placed between the gum and lip. This often lessens with continued use.
• Soreness or tenderness in the gum, especially if the pouch is consistently placed in the same spot. Rotating placement can help.
• Dry mouth due to the effects of nicotine on saliva production. Staying hydrated is beneficial.
• Mild throat irritation, especially if saliva with dissolved nicotine is swallowed.

These systemic effects like feeling sick (nausea) or light-headedness (dizziness) are more common if you try nicotine pouches with a nicotine content, that is too high for your individual tolerance or if you’re new to nicotine. Your body may react negatively to a sudden or excessive intake of nicotine. Starting with a lower nicotine level per pouch allows your system to gradually adjust to the effects of nicotine, significantly reducing the likelihood of these unpleasant sensations. Pay close attention to the nicotine levels indicated on the packaging of EDGE, Velo, Zyn, Nordic spirit, or any other nicotine pouch brands and opt for a lower strength initially.

Some individuals using pouches report experiencing hiccups. While the precise mechanism behind this side effect remains under investigation, it's theorized that nicotine might irritate the diaphragm or affect nerve pathways involved in the hiccup reflex. This effect is usually temporary and tends to subside as your body becomes more accustomed to the use of nicotine pouches. If hiccups persist or become bothersome, reducing the frequency of using pouches or trying a different brand might offer relief.

While dry mouth is a potential effect, some using pouches may experience the opposite: increased saliva production. This is a natural bodily response to the presence of a foreign object in the mouth and the taste or ingredients in nicotine pouches. As mentioned previously, while accidentally swallowing small amounts of saliva is generally not a major concern, it's often recommended to avoid intentionally swallowing large quantities, as it can sometimes lead to mild stomach upset due to the dissolved nicotine.

Headaches can occur, particularly during the initial stages of nicotine use as your body adapts to the substance. Nicotine can affect blood vessels and neurotransmitter levels in the brain, potentially triggering headaches. Ensuring you maintain adequate hydration and starting with an appropriate nicotine strength that isn't overwhelming for your system can help minimize the occurrence and severity of headaches. If headaches persist or become severe, it's advisable to consult a healthcare professional.

Nicotine is a known stimulant, similar to caffeine, and can interfere with your natural sleep-wake cycle. Using nicotine pouches too close to bedtime can make it harder to fall asleep and may also disrupt the quality of your sleep. Leading to restless nights and daytime fatigue. If you notice that using pouches, especially in the hours leading up to sleep, is affecting your ability to get restful sleep, try adjusting the timing of your nicotine use and avoiding them at least a few hours before going to bed.

It is paramount to understand that nicotine is an addictive substance, and nicotine pouches contain nicotine. Regular use of nicotine pouches can readily lead to nicotine addiction or nicotine dependence. The way nicotine interacts with the brain's reward system makes it habit-forming. Even though nicotine pouches don’t contain tobacco and eliminate many of the health risks associated with smoking cigarettes or smokeless tobacco products like snus or chew, the risk of nicotine addiction remains a significant health risk associated with oral nicotine products. The effects of nicotine on the developing brains of adolescents and young adults are particularly concerning, potentially leading to long-term cognitive and behavioural issues.